Centrifugal compressors are an established technology and have a variety of industrial applications. One of such applications is its extensive deployment in oil and gas production. For many years, centrifugal compressors have been at the heart of oil and gas productivity. This remains the same today and is likely to be the case in the immediate future. This publication explores the important distinguishing features of centrifugal compressors that are used in oil and gas field applications. It also provides guidance on how best to optimize their design and operation.